BMP4 and Peripheral demyelination: However, there was no significant difference in the integrated density of IBA-1 immunofluorescent between mice infused with LDN-193189 and vehicle following 1 week of recovery [Fig. 3B (quantified in D); p = 0.61i], suggesting that LDN-193189 exerted no significant influence on microglia during remyelination in vivo. Together, these data suggest that blocking BMP4/BMPRI signaling in the murine cuprizone model of demyelination exerts little effect on either astrocytes or microglia, but rather selectively enhances OPC differentiation to promote myelin repair in vivo.