TNNI3 and coronary artery disorder: Given an FDR of 5%, 9 gut microbiota CAGs were significantly correlated with 14 metabolic modules, as demonstrated through Spearman correlation coefficients, and these metabolic modules were further correlated with the Gensini score, number of stenosed vessels or cTnI level, which can represent the CAD severity (Fig. 3 and Additional file 2: Table S6).