Another study that characterized the genetic events underlying uterine leiomyomas by means of whole genome sequencing and gene expression analysis uncovered four distinctive pathways, ranging from oncogenic stress from MED12 aberrations, metabolic stress from inactivation of FH to complex chromosomal rearrangements induced by chromothripsis-like events and a variety of simple gene rearrangements [16]. This evidence concerns the gene FH and uterine corpus leiomyoma.