Functional activity of PPARs in cancer is related to their modulation of phosphates and kinases, including ERK1/2, P38-MAPK, PKC, AMPK, and GSK3 and although all PPAR isoforms are implicated in several metabolic syndromes, PPAR-γ seems to be mostly involved in tumorigenesis regulation via activation of these pathways [6]. Here, PPARG is linked to cancer.