SLC1A5 and non-small cell lung carcinoma: The majority of tumors haveTKTL1 protein up-regulated and GLUT1 expressed simultaneously; indeed, several studies reported that SLC1A5 is expressed in 66% of patients suffering from NSCLC [30] and targeting SLC1A5 in non-small cell lung cancer cells induces apoptotic cell death by impairing their ability to uptake sufficient glutamine from the extracellular environment [31].