However, in the follow-up study of Tadic et al.’s work, the predictor function of CpG-87 of BDNF exon IV promoter was not replicated, but in a subgroup of patients with severe depression, patients with hypermethylation at CpG-87 had significantly higher remission rates than patients without a methylation [57]. This evidence concerns the gene BDNF and depressive symptom measurement.