EDN1 and endothelial dysfunction: It seems, therefore, a reasonable attempt to assess the usefulness of NVC in young patients with RP, on the one hand, to assess the qualitative abnormalities in the nailfold videocapillaroscopy to monitor the course of RP, and on the other, the analysis of the relationship between structural changes in NVC and the concentration of endothelial damage biomarkers (sE-selectin, endothelin-1), lipid fractions and hsCRP in children and adolescents with the Raynaud phenomenon in the aspect of the risk assessment of subclinical vasculitis with possible inflammatory endothelial dysfunction.