An additional layer of VEGF-A regulation has been uncovered, whereby microRNAs (particularly miRNA-297 and -299 in tumour-associated macrophages; and miR-574-3p in human myeloid cells) bind to the CA-rich element (CARE) in the 3′ UTR of VEGF-A, which results in the negative regulation of VEGF-A expression [69,70]. The gene discussed is VEGFA; the disease is neoplasm.