In dextran-sulfate-sodium-induced colitis murine model, dietary crocin significantly decreased the expression of pro-inflammatory cytokines and inducible inflammatory enzymes such as TNF-α, IL-1β, IL-6, IFN-γ, NF-κB, cyclooxygenase-2, and inducible nitric oxide synthase and increased Nrf2 expression. Here, NOS2 is linked to colitis.