A mechanism involving RAC1 has been reported to involve the PI3K/AKT-RAC1-JNK axis in gastric adenocarcinoma [82], PI3K in squamous lung cancer [83,84], and the activation of STAT3 in colorectal cancer [85], highlighting the direct association of RAC1 activation and tumor aggressiveness. This evidence concerns the gene RAC1 and neoplasm.