According to the results, in patients having various diseases, such as rheumatoid arthritis, back pain, diabetes mallets, arthritis, gastritis, sebaceous cyst, osteoarthritis, and hepatitis c virus, all abnormal levels of complement C3 returned to normal values, while abnormal C4 levels did not change when patients were exposure to natural BV [29]. The gene discussed is C4A; the disease is rheumatoid arthritis.