The opposite effect of rs4804803 on the development of severe dengue is not inexplicable in consideration the role of DC- SIGN in ADE and DENV-dependent platelet activation: the expression of DC-SIGN was inversely correlated with ADE, but positively correlated with DENV-dependent platelet activation [21,22,46]. The gene discussed is CD209; the disease is acute disseminated encephalomyelitis.