Using PCa xenograft (LNCaP) model of castration resistant PCa (CRPC), the authors assessed the transcriptional signature representing the adaptive tumor response to androgen dihydrotestosterone (DHT) inhibitor enzalutamide (ENZ), revealing significant upregulation of NRP1 in metastatic samples (mCPRC), compared to localized PCa samples. Here, NRP1 is linked to posterior cortical atrophy.