The kinase signaling group consists of germline or somatic mutations in RET proto-oncogene (syndrome MEN 2A, 2B), neurofibromin 1 (NF1), transmembrane protein 127 (TMEM127), MYC-associated factor X (MAX), kinesin-like protein (KIF1BB), receptor tyrosine kinase (MET) and GTPase, Harvey rat sarcoma viral oncogene homolog (HRAS) with adrenergic or mixed noradrenergic and adrenergic secretory profiles [10,15]. The gene discussed is TMEM127; the disease is multiple endocrine neoplasia type 2A.