HCV infection and replication in CD4+ T cells result in a reduced proliferative capacity, an enhanced Fas-mediated apoptosis, and the suppression of IFN secretion [87,123], whereas the infection of B cells via the interaction with CD21, CD19, and CD81 complexes [124] can result in malignant lymphoma, since peripheral B cells serve as a reservoir for HCV [125]. This evidence concerns the gene CD4 and infection.