Direct comparison of the effectiveness of SMO vs. GLI antagonists in a large number of BC cell lines (MCF-7, T47-D, MDA-MB-231, MDA-MB-468, MDA-MB-453, BT-474, and SK-BR-3, and mouse TUBO) showed that GANT61 was superior to GDC-0449 [197]. The gene discussed is GLI1; the disease is breast cancer.