SHH and breast cancer: In ER-positive BC, increased GLI1 expression correlated with early disease onset, increased SHH expression [111], high Ki-67 index [4], higher histological grade [4,10,197], advanced tumor stage [4,10,103], lymph node involvement [4,10,103], metastasis [4], and shorter overall survival and disease-free survival [98,103,199] (Table 2).