IGF1 and breast cancer: In one multi-site study of high-risk premenopausal women to investigate the effect of atorvastatin on mammographic density (MD) and serum IGF-1 levels, both associated with increased risk of BC, found that this lipophilic statin did not reduce MD and indeed increased IGF-1, despite reducing serum cholesterol [239] (NCT00914017) (Table 3).