Whole genome expression studies using microarrays have led to classification of BC into five different subtypes of breast carcinomas based solely on clustered gene expression: luminal A (ER+ and/or PR+, HER2−, low Ki-67), luminal B (ER+ and/or PR+, HER2−/+, high Ki-67), HER2-overexpressing (ER−, PR− and HER2+), basal-like (express markers of basal/myoepithelial cells), and normal breast-like (enriched in markers of adipose cells/normal mammary cells) [12]. The gene discussed is ESR1; the disease is breast carcinoma.