These comprise the association of several SNPs in both the FOXO3 and BAX genes (including the PACT significant rs4645887 variant in BAX) with CRC risk, significance of FOXO3 for overall gene variation, and several significant findings of SNP x Se and gene x Se status interactions for genes in this pathway (e.g., SMAC, CASP8, MAPK8, and MAPK9). The gene discussed is CASP8; the disease is colorectal carcinoma.