Associations of multiple SNPs in the same gene (several of which are novel) with CRC risk were observed in genes from pathways 2–8, e.g., BAX, GPX5, FOXO3, IL12B, TLR4, MSH2, MSH3, TGFB1, as well as IL10 with rectal cancer risk. The gene discussed is IL12B; the disease is rectal cancer.