These 12 selenoprotein genes include those previously found associated with CRC risk (GPX1, GPX4, SELENOF, TXNRD1, TXNRD2, TXNRD3; for reviews, see [4,21]) and several with limited prior or no previous evidence of association with CRC risk (DI01, GPX6, SELENOM, SELENON, SELENOT, SELENOV). The gene discussed is TXNRD1; the disease is colorectal carcinoma.