Additionally, several of these genes (e.g., GPX1, GPX5, LRP2, SEPHS1, SELENOM, SELENON, TXNRD1, and TXNRD2) had multiple SNPs and/or SNPs with raw P-values < 0.01 associated with CRC risk further supporting a role of selenoproteins, selenoprotein metabolism, ER stress, and oxidative stress in CRC development. The gene discussed is SEPHS1; the disease is colorectal carcinoma.