GPX4 and colorectal carcinoma: None of the 3 GPX1 SNPs (rs17080528, rs3448, rs9818758) or rs2074451 in GPX4 associated with CRC risk are in high LD (i.e., r2 ≥ 0.8) to the functional GPX1 Pro/Leu rs1050450 and GPX4 rs713041 SNPs (for which the Illumina assays failed) previously implicated in prostate, breast, lung (rs1050450), and CRC risk (rs713041) [4].