In pathways 3–8, considering genes with multiple SNPs associated with CRC risk or SNPs with raw P-values < 0.01 for at least one genetic model, there were several notable and some novel associations with CRC risk for genes in pathways 3 (C-MYC, FRZB), 4 (APAF1, BAX, FOXO3), 5 (IL12B, RPS6KA2, TRL4), 6 (MSH2, MSH3) and 7 (BMP2, BMPR2, SMAD3, SMAD7, TFGB1). This evidence concerns the gene APAF1 and colorectal carcinoma.