Neither gene only variation or interactions with Se status in the core pathway 1 selenoprotein and biosynthesis pathway were associated with CRC risk by pathway, although gene only variation for GPX1, SELENOM, SELENON, and SEPHS1 plus gene x Se status interactions for SELENON (with SELENOP) and PSTK (with Se) were associated with CRC risk. Here, SELENON is linked to colorectal carcinoma.