TP53 and neoplasm: Especially, the mutation in tumor suppressive genes are more significantly involved in tumorigenesis and Tumor protein p53 (TP53), Breast cancer type 1/2 susceptibility protein (BRCA1/2), and Phosphatase and tensin homolog (PTEN) which protect DNA from mutation accumulation have been suggested as frequently mutated tumor suppressor genes in tumor cells [2].