They are expected to reduce cancer cell proliferation and metastasis, because increased D-2HG has been shown to induce EMT through mechanisms, such as DNA hypermethylation, TET methylcytosine dioxygenase 2 (TET2) dysfunction, and increased HIF-1α and serum Vesicular endothelial growth factor (VEGF) levels [149,150,151]. The gene discussed is HIF1A; the disease is cancer.