Nuclear PKM2 binds to TGFB induced factor homeobox 2 (TGIF2), which is a transcription factor of Cadherin-1 (CDH1), and represses CDH1 transcription and stimulates the mesenchymal marker, vimentin, during EMT both in in vitro and in vivo colorectal cancer models. Here, TGIF2 is linked to colorectal cancer.