Altogether our results suggest that DUSP6 maintains a transcriptional program that represses EMT and tumorigenicity by downregulating ERK5 phosphorylation, inhibiting of EGF/EGFR, TGF β, WNT and interleukin signaling pathways involving VAV3, SNAI1, SNAI2 and ZEB1, among others, hence acting as a tumor suppressor. Here, DUSP6 is linked to neoplasm.