To investigate the role of DUSP6 in lung cancer, we analyzed the expression profile of DUSP6 from publicly accessible large datasets of NSCLC, deposited in Gene Expression Omnibus (GEO) and the two different types of lung cancer LUAD (Lung Adenocarcinoma) and LUSC (Lung Squamous Cell Carcinoma), deposited in The Cancer Genome Atlas (TCGA) databases. This evidence concerns the gene DUSP6 and squamous cell lung carcinoma.