These findings were corroborated by de Boer et al., who found Gal-3 to be an independent predictor of adverse outcomes (all-cause mortality and HF hospitalization) in HF patients (HR 1.38, 95% CI 1.07–1.78, p = 0.015), especially those with preserved LVEF [52]. Here, LGALS3 is linked to hydrops fetalis.