This patient had pleural effusion, renal involvement (abnormal creatinine, hematuria, and proteinuria), hemocyte decrease, hypocomplementemia, and raised antibody titer (ANA cytoplasm 1:1000 [+], anti-dsDNA antibody: 109.91 IU/ml, anti-SSA 114 [+++]). This evidence concerns the gene BTG3 and Pleural effusion.