MUTYH and colorectal carcinoma: Moreover, decreased efficiency of DNA repair was shown to be correlated with MUTYH Gln324His (CAG/CAC) genotype occurrence in CRC patients, suggesting a role in tumor pathogenesis.[17,18] Another study by Singh et al[19] suggested that MUTYH Gln324His (CAG/CAC) increases the risk of lung adenocarcinoma susceptibility.