8-Oxo-G is generated by a hydroxyl radical whereas 2-OH-A is exclusively generated by oxidation of dATP in the nucleotide pool.[25,34] The 2-OH-A level is enhanced in cancerous cells.[35] Thus, in cervical carcinoma, enzyme activity of MUTYH Gln324His may be partially impaired. The gene discussed is MUTYH; the disease is cervical carcinoma.