EGF and neoplasm: EGF is released by cells and then binds to its receptor (EGFR) on either the cell itself, stimulating its own growth, or on neighboring cells, stimulating the ability of the cells to divide (Goodsell, 2003), while CXCL1 (bind to CXCR2) plays a role in the immune response, attracts CD11b+Gr1+ myeloid cells into the tumor, and enhances the survival of tumor cells facing the challenge of invading new microenvironments, tipping the balance from immune protection to tumor promotion (Acharyya et al., 2012; Yan et al., 2010).