Moreover, the presence of TNF-α inhibited infection of Vero cells infected with CHIKV LR2006-OPY1 as measured by reduced CPE in the monolayers with as little as 5 pg/ml [Fig 6D], and an IC50 of 14.49 ± 2.99 as determined by nonlinear regression using GraphPad Prism software. The gene discussed is TNF; the disease is infection.