This rearrangement is reported in Ph-like acute lymphoblastic leukemia subtype, a particularly aggressive subtype.30 The molecular profiling has changed the diagnosis for patient 73, who initially received a Ewing-like sarcoma diagnosis on the basis of histologic appearance and immunohistochemistry, but the EWSR1 (2130) and FUS (2521)–derived fusions were not detected by fluorescence in situ hybridization analysis. Here, EWSR1 is linked to acute lymphoblastic leukemia.