SCN1A and Dravet syndrome: These results suggest Scn1aΔE26 mice are phenotypically similar to global and inhibitory neuron-specific Scn1a haploinsufficient models of DS (Yu et al., 2006; Kalume et al., 2013; Kim et al., 2018), but with an accelerated time course for manifestation of pathological features including spontaneous and heat-induced seizures as well as premature death.