SCN1A and Dravet syndrome: Consistent with this possibility and analogous to cortical inhibitory neurons in Scn1a-/+ knockout models (Cheah et al., 2012) and induced pluripotent stem cells derived from DS patients with an Scn1a truncation mutation (Higurashi et al., 2013), we found that inhibitory neurons in the RTN region expressed the Scn1a A1783V pathological variant produced fewer action potentials in response to sustained depolarizing current injection and were more prone to depolarization block compared to inhibitory neurons from control mice (Figure 4A–D).