RAB5A and Timothy syndrome: In contrast, cortex glial knockdowns of Rab5, a Rab GTPase regulator of early endosome (EE) dynamics (Dunst et al., 2015; Langemeyer et al., 2018), and Endophilin A (EndoA), a BAR-domain protein involved in early stages of endocytosis (Verstreken et al., 2002), were found to be viable (Figure 2—figure supplement 1A) and to completely suppress zyd TS seizures (Figure 7A, Figure 7—video 1).