SYNGAP1 and Anxiety: Prior studies have shown that reduced Syngap1 expression during this developmental critical period prevents the normal emergence of certain behavioral responses and cognitive functions because altered measures of working memory, locomotor activity, and anxiety are sensitive to neonatal reversal of Syngap1 pathogenicity (Aceti et al., 2015) but resistant to similar approaches performed in adulthood (Clement et al., 2012).