PIK3CB and non-small cell lung carcinoma: However, we failed to observe any consistent activation of PI3K/AKT signaling in the three datasets, as PI3K/AKT signaling was upregulated in gemcitabine‐resistant Calu3 cell line but downregulated in taxane‐platin‐resistant NSCLC cell line (H1299 or H1355).30 Janus kinase/signal transducer and activator of transcription (JAK‐STAT) signaling pathway have been reported to be upregulated in allopurinol‐resistant cell lines, but we failed to report similar observation in either taxane‐platin‐resistant cells or gemcitabine‐resistant cells.