As per our results, MAPK signaling was synergistically upregulated with NAMPT expression.45 In addition, NAMPT has also been associated with chronic inflammation in pancreatic cancer and is thought to contribute to drug resistance.46 The knockdown of NAMPT expression significantly increased the apoptosis of cisplatin‐resistant A549 tumor cells following cisplatin treatment. The gene discussed is NAMPT; the disease is pancreatic neoplasm.