PRKCE and early-onset autosomal dominant Alzheimer disease: Concerning the CNS, PKCε phosphorylation has been shown to increase the activity of endothelin converting enzyme (ECE), which is responsible for amyloid beta clearance, via an N‐terminal modification site.152 This would indicate that PKCε may be downregulated in Alzheimer's disease,153 and restoring PKCε activity could be neuroprotective similar to how PKCε activity is observed in cardiac tissue.