Previous studies showed that other ALS‐associated ANG mutations (S28N, L35P, P112L, K17I, K17E, Q12L) also result in partial or complete loss of nuclear translocation capability due to the changes in the folding of the 31RRR33 residues and subsequent reduction in SASA (Bradshaw et al., 2017; Padhi et al., 2014; Thiyagarajan, Ferguson, Subramanian, & Acharya, 2012; Wu et al., 2007). The gene discussed is ANG; the disease is amyotrophic lateral sclerosis.