Several cellular proteins have been reported to interact with LANA, including ATF4/CREB2/STAT3 for transcription, p53/pRb/von Hippel Lindau (VHL) for tumor repression, HP1/H2A/H2B/MeCP2/BRD4 for chromatin binding, and GSK-3β for signal transduction (Cai et al.2006; Fujimuro et al.2005; Garber et al.2001; Griffiths and Whitehouse 2007; Jr et al. 1999; Lim et al.2000; Ottinger et al.2006; Radkov et al.2000). Here, ATF4 is linked to neoplasm.