The proposed PTPN2 substrate Met was found to be associated with PTPN2, membranous and cytoplasmic phosphorylated Met were more often positive in PTPN2-positive tumours, which was specifically apparent in the Luminal A subtype (cytoplasmic pMet: p < 0.005 and membranous pMet: p = 0.038). This evidence concerns the gene PTPN2 and neoplasm.