For instance, Keynote 012 Phase 1b anti-PD-1 antibody (pembrolizumab) trial treated a cohort of 60 R/M HNSCC patients positive for PD-L1 expressing tumors (>1% via IHC staining), with 10 mg/kg every 2 weeks. The gene discussed is CD274; the disease is head and neck squamous cell carcinoma.