Mechanistic studies of cetuximab-induced immune modulation, either cetuximab alone or in combination with anti-CD137, illustrated that cetuximab activates NKs and DCs via Fc receptor-dependent pathway, subsequently leading to the activation of Th1/CTL responses and elevated APM for activation of tumor-specific T cells (Srivastava et al., 2017). This evidence concerns the gene TNFRSF9 and neoplasm.