CD274 and head and neck squamous cell carcinoma: Colevas et al. (2018) reported the results of a phase 1a trial of 32 HNSCC patients receiving anti-PD-L1 every 3 weeks, which showed an ORR of 22% and no clear differences between HPV (+) and HPV (-) patients. The results of other trials are yet to be reported (Cavalieri et al., 2018).