Similarly, our multiplex IHC analysis also showed a heterogeneous loss of epithelial markers, including EpCAM and cytokeratin in HNSCC tumors examined as previously reported (Ambatipudi et al., 2013; Baumeister et al., 2018; Pan et al., 2018; Sequeira et al., 2018). The gene discussed is EPCAM; the disease is head and neck squamous cell carcinoma.