CD8A and neoplasm: At the molecular level, tumor-induced immunoevasion and immunosuppression are associated with downregulation of MHC molecules (human leukocyte antigen, HLA), inactivation of the APM, which prevents the processing and presentation of tumor antigens to CD8 T cells, and upregulation of the checkpoint inhibitors on tumors and immune cells (Ferris et al., 2006; Lopez-Albaitero et al., 2006).