IHC analysis also demonstrates a heterogeneous loss of epithelial markers, including epithelial cell adhesion molecule (EpCAM) or Keratin 76 (Krt76), in clinical specimens of HNSCC or oral SCCs, respectively, leading to more aggressive tumor progression and altered immune landscape (Ambatipudi et al., 2013; Baumeister et al., 2018; Pan et al., 2018; Sequeira et al., 2018). Here, EPCAM is linked to head and neck squamous cell carcinoma.