In mice model for atherosclerotic- and human atherosclerotic-blood vessels, very high YAP/TAZ activity was observed (Wang K.C. et al., 2016; Wang L. et al., 2016), indicating mechanotransduction of YAP/TAZ is responsible for pathological effects of disturbed blood flow during atherosclerosis. The gene discussed is YAP1; the disease is atherosclerosis.