The emerin p.D149H phenotype is opposite to that seen in LMNA-associated metabolic disease, especially for triglycerides and waist circumference, both of which are elevated in LMNA-associated lipodystrophy, insulin resistance and metabolic syndrome (Decaudain et al., 2007; Vadrot et al., 2015; Dutour et al., 2011; Brayson and Shanahan, 2017). Here, EMD is linked to lipodystrophy.