The activation of signaling pathways such as High Mobility Group Protein B1 (HMGB1), Triggering Receptor Expressed on Myeloid cells-1 (TREM1), interleukin 6 (IL-6), and acute phase response signaling was predicted in both R. conorii- and R. montanensis-infected macrophage-like cells, which is consistent with an augmented inflammatory response upon infection. The gene discussed is TREM1; the disease is infection.