Although SopB mediates sustained activation of the pro-survival kinase Akt in infected epithelial cells (Knodler et al., 2005), and moreover, Akt2 deficiency mice display increased susceptibility to Salmonella infection (Kum et al., 2011), the role of SopB in vivo is not clear to now. Here, AKT2 is linked to Salmonella Infections.