METTL3 and acute myeloid leukemia: In particular, in a first study performed on the MOLM-13 AML cell lines, which carries the FLT3 internal tandem duplication (FLT3-ITD) that in patients is associated with a more aggressive disease, knockdown of METTL3 resulted in a m6A dependent reduction of c-MYC, BCL2 and PTEN mRNA translation while the overexpression of METTL3 produced increased protein levels of all three proteins (37).