RBM15 and acute myeloid leukemia: Strikingly, it was shown that the effect of RBM15 in the hematopoietic system and AML was partly due to deregulation of the Notch signaling (31, 34) and regulation of c-MYC expression (33), which were later identified as relevant m6A targets in haematopoiesis and AML (35–38).