We further observed a synergistic increase in MM cell apoptosis (Figure 2) and ubiquitinated protein accumulation with the combination of MPT0G413 and BTZ, compared to either single-agent therapy (Figures 3C,D) and determined that this effect was mediated by the inhibition of the proteasomal and aggresomal pathways. Here, CASC3 is linked to Miyoshi myopathy.