Meanwhile, the number of F4/80 labeled TAMs (Figures 6D,E), the number of CD163 labeled M2 TAMs (Figures 6D,E), and the Ki-67 index (Figures 6D,F) in the tumor tissues were significantly reduced in the CCR2 antagonist group than those in the control group (P < 0.01). This evidence concerns the gene MKI67 and neoplasm.