Mechanistically, they act through the cell to cell contact and largely by their secretome including various angiogenic factors, comprising vascular endothelial growth factor (VEGF), interleukin-8, and platelet-derived endothelial cell growth factor (PDGF) in gastric cancer that help tumor progression through escaping the active antitumor immunity (9). The gene discussed is VEGFA; the disease is gastric cancer.