TGFB1 and neoplasm: CD4+CD25hi+Foxp3+ regulatory T cells are known with their inhibitory activity, largely by production of TGF-β and play a critical role in preventing autoimmunity and tumor progression (35), while IL-17 producing RORγ+ Th17 cells have well-described roles in autoimmune disease, although their role in tumor immunity remained unknown (36).