Moreover, fibroblasts gradually recruit from bone marrow to stomach in response to produced TGF-β and SDF-1α following the inflammation caused by H. pylori, to inhibit inflammation and repair the injury, however chronic inflammation derived-dysplasia differentiates them to cancer-associated fibroblasts (CAFs) with the potential to gastric cancer development (8). The gene discussed is TGFB1; the disease is gastric cancer.