Specifically, there is an abundance of immunosuppressive cell types such as myeloid-derived suppressor cells (MDSC) (88–90), tumor-associate macrophages (TAM) (91), and regulatory T cells (Treg) (26, 92–95), as well as cytokines such as transforming growth factor beta (TGFβ) and indoleamine 2,3 dioxygenase (IDO) (26, 96), that have been shown to interact with NK cells and cause phenotypic and functional dysfunction. Here, TGFB1 is linked to neoplasm.