ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: The mice model of CML used before varied according to different purposes, for example, we gained solid tumor models directly by subcutaneous injection, we inoculate the CML cells via tail vein and transfer the primary BM cells retro-virally transduced with p210Bcr-Abl into B6 mice intravenously according to the standard BM transplantation (BMT) procedure (32, 44).