AKT1 and chronic myelogenous leukemia, BCR-ABL1 positive: The mechanisms of Oroxylin A on improving the sensitivity of CML cells to IM might be related to the suppression of CXCL12/CXCR4 axis and its downstream pathway, Akt/GSK3β/β-catenin/ P-gp, in vitro and in vivo.