Also, our previous studies has demonstrated that Oroxylin A was able to reverse IM resistance in CML cells by inhibiting the CXCR7/ERK pathway, CXCR4/PI3K/Akt/NF-κB pathway and blocking the expression of P-gp by suppressing Stat3 pathway in the co-cultured group (31–33). This evidence concerns the gene AKT1 and chronic myelogenous leukemia, BCR-ABL1 positive.