DHPS and malaria: The orthologous gene encoding DHS enzyme in the murine malaria parasite P. berghei is essential, since clonal transgenic P. berghei parasites with knockout of the DHS gene cannot be isolated (Kersting et al., 2016), and P. berghei DHS knockout parasites have a severe growth defect causing them to rapidly disappear from host animals co-infected with other transgenic parasites (Bushell et al., 2017).