The data on the role of PI3K/Akt pathway deficiency in the development ofβ-cell apoptosis in DM, along with the data on the involvement of thispathway in the implementation of the antihyperglycemic effect of GK-2 [42], suggest that the protective effect ofGK-2 is also associated with the ability of this NGF mimetic to activate theabovementioned pathway. The gene discussed is NGF; the disease is diabetes mellitus.