For instance, in breast cancer cells, CDK12 overexpression led to altered alternative last exon splicing of a subset of genes (Tien et al., 2017) and increased the invasiveness of a breast cancer cell line by decreasing the expression of the long isoform of DNAJB6 (Paculová and Kohoutek, 2017). This evidence concerns the gene DNAJB6 and breast cancer.