A selection of eight SNPs to construct IVs (rs2250417, rs2300702, rs2268797, rs6748621, rs7577696, rs6760105, rs212745, and rs212713) satisfied all conditions, including strong associations with IL-18 phenotypes (P < 5 × 10−8, β ≠ 0) and no association with T2DM (P > 0.05) or LD effect (Table 1). The gene discussed is IL18; the disease is type 2 diabetes mellitus.