IL18 and type 2 diabetes mellitus: The pooled causal effects from the MR-Egger regression analysis are consistent with the IVW results: an estimated bate of T2DM per SD higher IL-18 plasma level was 0.122 (95% CI 0.003 – 0.221, P = 0.044); the intercept size was 0.011 (95% CI -0.004 to 0.026, P = 0.158), suggesting that all variants were valid.