No heterogeneity was found between variants of the summary data (P = 1.0 and I2 = 0%; Figure 3); the fixed-effect model was applied for the meta-analysis, and the OR of T2DM per SD higher IL-18 plasma level was 1.14 (95% CI 1.03 – 1.26, P = 0.0117; Figure 3). This evidence concerns the gene IL18 and type 2 diabetes mellitus.