In the non-genomic pathway, the liganded ERα and ARα activate RAS, which activates BRAF, which activates MEK, which activates ERK, also known as MAPK, which can phosphorylate and therefore activate CREB in the genomic pathway or can directly enhance proto-oncogene transcription and melanoma proliferation (Mitkov et al., 2015). The gene discussed is CREB1; the disease is melanoma.