CD8A and systemic sclerosis: In the ROC curve analysis for GD/SSc patients as compared with healthy controls in the CD8+ subset, the methylation levels of the 2 DMS (P-value after FDR of cg06872964 was 0.031, which is higher than our definition of DMS, and thus not included) showed AUC value of 0.75, with sensitivity of 0.89 and specificity of 0.52 (Supplementary Figure 15B and Supplementary Table 8).