Using cell immunofluorescence, we demonstrated that interleukin (IL)-17A, tumor necrosis factor (TNF)-α, high mobility group box-1 (HMGB1), and LCN2, all of which are elevated in psoriasis (4, 19, 32), were potent inducers of NETs formation, and comparable to induction by phorbol 12-myristate 13-acetate (PMA), which was used as a positive control (Figure S1B). Here, HMGB1 is linked to psoriasis.