To address the potential role of LCN2 in this process, we neutralized LCN2 using antibody in two mouse models of psoriasis (Figure S6A), the IMQ model and the transgenic K14-VEGF model (42, 43), and after 7 or 14 consecutive days, marked reduction in acanthosis and the number of Ly-6G labeled neutrophils was observed (Figures 6H,I; Figures S6B–D). The gene discussed is VEGFA; the disease is psoriasis.